Alternative Role for Alternative Splicing



  • ...RNA surveillance and gene.


    Steven Brenner (bio), Assistant Professor - U.C. Berkeley

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    Presentation Overview

    Alternative Role for Alternative Splicing

    More than one third of all human genes are alternatively spliced, yet the functional consequences of alternate isoforms remain largely unknown. In a comprehensive analysis of reliably-inferred human alternative isoforms, we discovered that many are candidates for nonsense-mediated mRNA decay (NMD), an RNA surveillance system. It may be that these transcripts are subjected to regulated unproductive splicing and translation (RUST), which is a general mechanism of controlling protein expression that been established for a handful of genes. We are currently working to experimentally verify the role of NMD in several genes whose mutations and aberrant expression have been linked to disease.

    This talk will review the biological mechanisms of alternative splicing and nonsense-mediated decay, and the computational methods used to infer their action. I will describe our computational and experimental studies of natural human genes targeted for NMD. The talk will conclude with hypotheses regarding the coupling of alternative splicing and NMD for RUST.


    About the Presenter


    Steven Brenner, Assistant Professor at U.C. Berkeley

    Steven E. Brenner is an Assistant Professor and leader of a computational genomics research group at the University of California, Berkeley. His research interests include computational approaches for structural genomics and sequence analysis, and the use of both of these to infer molecular function. A recent new direction in his group involves RNA biology and gene regulation. Brenner was educated and trained at Harvard University, the MRC Laboratory of Molecular Biology and Cambridge University, the Japan National Institute of Bioscience, and Stanford University. His honors include being named a Searle Scholar and an Alfred P. Sloan Research Fellow. He is a director of the International Society for Computational Biology and is a founding director of the Open Bioinformatics Foundation.


    Event Logistics


    SFSU Cel Downtown
    425 Market Street, 26th Floor, Room 2608
    San Francisco, CA

    Note: Location provided courtesy of Hanson, Bridgett, Marcus, Vlahos, Rudy, LLP.


    6:30-7:00pm registration/networking
    7:00-9:00pm presentation


    $15 at the door for non-SDForum members
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