BioInfo SIG: Informatics & Visualization
Tools for Pharmacogenetics Research
Pharmacogenetics is the study of the genetic basis for variation in drug response from person to person. UCSF has recently undertaken a major research project, the Pharmacogenetics of Membrane Transporters (PMT), whose goal is to understand the pharmacogenetics of drugs which interact with membrane transporters. Membrane transporters play a major role in drug response in two ways. First, many drugs work by affecting the function of transporters. Secondly, transporters determine the level of drugs within the body and thus determine whether drug levels are adequately high for therapeutic effect but not so high as to have adverse or toxic effects. The PMT project involves determining sequence variants in genes encoding selected membrane transport proteins in a population of several hundred ethnically diverse individuals, and determining the cellular and clinical phenotypes associated with specific transporter variants. Included in this project is the development of a set of bioinformatics tools for the large-scale data collection, storage, analysis, and presentation of experimental results. These tools will be described, including a demonstration of the Chimera molecular graphics system.
About the Presenter
Thomas E. Ferrin, Ph.D.
Dr. Ferrin is a Professor in the Departments of Pharmaceutical Chemistry and Biopharmaceutical Sciences at the University of California, San Francisco. He is also chair of the UCSF Graduate Program in Biological and Medical Informatics, and is Director of the UCSF Resource for Biocomputing, Visualization, and Informatics, a NIH National Center for Research Resources Biomedical Technology Research Center. He received a B.S. degree in Electrical Engineering and Computer Science in 1971 from the Institute of Technology at the University of Minnesota, and his Ph.D. in Biomedical Informatics from UCSF in 1986.
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